Challenge Session Overview
Challenges Instructions- Finalised
The challenge instructions for Type 2 models have now been finalized (see below) and we are in the process of updating the Type 1 model challenge instructions.
The impact of model uncertainty on cost-effectiveness estimates of diabetes interventions is unknown. The aim of Mt Hood 2023 challenges is to replicate the challenges undertaken at Mt Hood 2022, but focusing on a set of simulations using an Asian reference patient.
Some aspects of the challenges will be updated, so the attached documents are for general information only and should not be used for the Asia conference. Updated information will be provided for those participating in the challenge.
If you have a diabetes simulation model and have not participated in an Mt Hood Challenge conference before, please email mthood2016@gmail.com so you can receive updates.
The challenge is broken into two components.
Challenge 1: Revisiting the reference simulation
We will also ask groups to repeat the reference simulations for a standard patent that were in previous challenges and reported in the MT Hood model registry. This will enable model simulations to be compared across time and across different models.
Challenge 2: Simulating costs and cost-effectiveness
Following the 2018 Mt Hood Quality of life Challenge, the challenge employs average values or characteristics of patients enrolled in RCTs of common diabetes therapies. The average treatment effect of each category of intervention will be modelled by permanent reduction in HbA1c and body mass index. Each category of intervention has the same treatment effect but differ in their costs. The results from this exercise will provide an indication of what factors influence the cost-effectiveness of these interventions. The challenge will also examine how then estimated incremental QALYs, costs and ICER vary for a cohort of patients with a history of myocardial infarction and following the inclusion of unrelated future medical costs.
Finally, we are currently in the process of finalizing the instructions for type 1 diabetes models participating in the challenge, these instructions will be made available from this page in due course.
Participation in publications arising from the meeting
In the past several groups participating in the conference have collaborated on a subsequent publication. Involvement in the publication process is on a voluntary basis and involves acceptance of the following principles:
i. No team can block publication of the paper except because of concerns related to scientific soundness — e.g., the data collection, analyses and presentation were done incorrectly.
Concerns related to policy, management, or scientific implications are not grounds for a co- author to block publication. If a majority of Team members believe the paper should be published based on sound science, the paper will move forward. Every reasonable effort should be made by the Leader and others to reach a consensus on moving forward with a publication.
ii. Teams may voluntarily remove themselves from the project, and from co-authorship, at any point if they no longer have time for the project or they disagree with some aspect of the project or paper. If a Team voluntarily leaves the project or is asked to leave because they
are opposed to the paper being published, the Team and Chair of Mt Hood Steering Committee will need to discuss with the dissenting member if his/her contributions can still be used, and perhaps described in the Acknowledgements, or if their contribution will have to be removed from the paper.
