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History of Mt Hood Diabetes Challenge

Why is a diabetes and economics simulation modelling conference named after a mountain? Back in 1999, two groups  who developed separate diabetes simulation model met at the ski lodge on the slopes of Mt Hood near Portland Oregon. They spent several days running identical simulations, so that they could compare the output of their models.

This was replicated a few years later with more modelling groups joining the challenge to compare and validate the results of their simulation models. Since then meetings have been hosted by researchers in either the US and Europe every couple of years including at Oxford, John Hopkins and Stanford Universities. The Mt Hood Diabetes Challenge has now become a regular conference devoted to the economics of diabetes, but always retained emphasis on comparative simulation modelling. Since 2019 it has included an Asian meeting in its cycle of conferences. 

Timberline lodge on Mt Hood, Oregon - site of the first Mt hood meeting 

The ongoing need for a dedicated conference remains, as health economic simulation models in diabetes have to capture the progression of a complex disease, in which multiple risk factors (including blood glucose and blood pressure) can impact on a wide variety of health outcomes including myocardial infarction, renal failure and blindness. Modelling the progression of diabetes and its complications forms the basis of most cost-effectiveness analyses of interventions to prevent and treat both Type 1 and Type 2 diabetes.

Since the first dedicated diabetes simulation model was developed by Richard Eastman back in the mid-1990s, many health economists have worked on computer simulation models for both Type 1 and Type 2 diabetes. Mt Hood provides an opportunity for these groups to test and cross validate their models against each other as well as validate them with real world data. For example, the 5th Mt Hood Challenge held at Lund University involved eight modeling groups, who were given four challenges. Most of the challenges at this meeting involved replicating the results of major diabetes trials including ADVANCE and ACCORD. Model outcomes for each challenge were compared with the published findings of the respective trials.

Recent challenges have focused on structural uncertainty and model reproducibility. The Mt Hood Challenge network has lead the way in health economics in the mass-replication of simulation models with up to a dozen groups running identical simulations for a range of health interventions for people with Type 2 diabetes.

This international conference now involves around 80 participants from a wide variety of backgrounds and allows simulation modelers to interact with those using models for economic and policy analysis. In addition to challenge sessions, the conference accepts abstracts to allow a wide variety of researchers undertaking work on economics aspects of diabetes to present their work.


(Some material from this history was originally posted as a blog). 

Timberline lodge on Mt Hood, Oregon - site of the first Mt hood meeting 

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