PROSIT Disease Modelling Community (Framework)
Information last updated: Feb 2019
Participated in following Mt Hood Diabetes Challenge Meetings: 2018
Publicly accessible?: All model versions are hosted in a wiki and they can be accessed via the model website.
Is the model continuing to be developed?: Yes.
Credibility and transparency of health-economic diabetes models is sometimes considered a problem. Therefore, the authors started in 2006 to develop open source models for the important medical complications of type 2 diabetes mellitus.
PROSIT is called by the authors a modelling framework as there is not a single diabetes model, but currently six diabetic complication models for Coronary Heart Disease, Stroke, Nephropathy, Retinopathy, Amputation, and Hypoglycaemia.
These are Markov models implemented as spreadsheet tables in OpenOffice.org and LibreOffice. All models are subject to a version control and old versions remain available online in order to assure the reproducibility of model calculations. They can be downloaded on the internet from the PROSIT Wiki.
The models are published online with a basic set of input data that can be easily changed according to the discretional choice of the user. The patient characteristics have been derived from the German ProValue study program. A cost data set for Germany was derived from the German KoDim-Study and reflects the year 2015. QALYs have been derived from the literature. The models allow the discounting of costs and effects. A separate validation toolkit allows the standardised validation by means of one-way sensitivity analysis of new model versions to allow comparison with previous models. The models due to their design do not support probabilistic sensitivity analysis.
The model framework is part of a higher education concept to link science with teaching. Thus, the core modellers are supported frequently by student contributions.
Funding source for model development:
The model development started with no funding whatsoever in 2006. In the time period 2010/2011 a non-restricted research grant from NovoNordisk, Denmark was received. Since 2015 the model development is supported by a research grant from Roche Diabetes Care Germany GmbH, Mannheim.
Schramm W, Sailer F, Pobiruchin M, Weiss C. PROSIT Open Source Disease Models for Diabetes Mellitus. Stud Health Technol Inform. 2016;226:115-8. PMID: 27350481
Seitz P, Fendrich L, Hempe H, Rickmann J, Christophidis B, et al. Validierung des PROSIT CHD Type 2 Diabetes Herzinfarktmodells. Diabetologie und Stoffwechsel 2017; 12(S 01): S1-S84. DOI: 10.1055/s-0037-1601719
The values below are simulated Quality Adjusted life Years (QALYs) for a set of reference simulations
0.5% red. HbA1c
10mmHg in SBP
0.5mmol/l red. LDL
1-unit red BMI